Related railways

• Atlantic, Quebec and Western Railway (Quebec Oriental)
• Canadian National Railway
• VIA Rail

New Carlisle's first station was built by the Quebec Oriental Railway which had a complicated history. It was taken over by CN in 1927. In 1942, an escaped German spy named Werner von Janowski escaped from a German submarine in Chaleur Bay, about six and a half kilometres west of the community. He boarded a train headed for Montreal but was captured shortly afterwards. The station was destroyed by fire in the 1940s.

CN replaced the station in 1947. The current station has historical status due to a number of important architectural features. It was part of a plan CN devised in the 1920s specifically for rural Quebec stations and is believed to be the only surviving example. The station was closed in 2013 when VIA discontinued service due to poor track and bridge conditions. Repairs to the infrastructure are ongoing and service is expected to be restored in 2026.